Syam Somasekharan
Assistant Professor
Research Classification
Research Interests
RNA Biology
Cell Biology
molecular biology
Biomolecular Condensates
Nucleolus
mRNA Translation
Liquid-liquid Phase Separation
Relevant Thesis-Based Degree Programs
Affiliations to Research Centres, Institutes & Clusters
Research Options
I am available and interested in collaborations (e.g. clusters, grants).
I am interested in and conduct interdisciplinary research.
I am interested in working with undergraduate students on research projects.
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Research Methodology
Relationship between RNA granule machinery and prostate cancer treatment resistance.
Role of epitranscriptomic (m6A) RNA modifications in the translational regulation of androgen receptor (AR) mRNA.
Mechanism of liquid-liquid phase separation (LLPS) of intrinsically disordered proteins - G3BP1, FMRP and YTHDF3- and RNA.
Molecular mechanisms of the control of gene expression at multiple levels - mRNA synthesis, transport, localisation and degradation.
Multiomics approach to profile RNA granules and define selective mRNA translation.
Nucleolus, phase separation, stress response, and treatment resistance.
Recruitment
Master's students
Doctoral students
Postdoctoral Fellows
2024
2025
- Nucleolus, phase separation, stress response, and treatment resistance.
- Multiomics approach to profile RNA granules and define selective mRNA translation.
- Molecular mechanisms of the control of gene expression at multiple levels - mRNA synthesis, transport, localisation and degradation.
- Relationship between RNA granule machinery and prostate cancer treatment resistance.
- Mechanism of liquid-liquid phase separation (LLPS) of intrinsically disordered proteins - G3BP1, FMRP and YTHDF3- and RNA.
- Role of epitranscriptomic (m6A) RNA modifications in the translational regulation of androgen receptor (AR) mRNA.
- Master's student: A recent BSc or BS with a passion for research and research experience in cell and molecular biology. Students without experience will also be considered.
- Doctoral student: A recent MSc or MS student with a passion for research and research experience in cell and molecular biology. Students without experience will also be considered.
- Postdoctoral Fellow: A recent PhD in cell biology, biochemistry, molecular biology, or related subject. The ideal candidate should be able to work independently, be passionate about cell biology, and be committed to conducting high-quality research. The candidate should have experience in techniques including RNA in situ hybridisation, RNA-electrophoretic mobility shift assay, immunofluorescence microscopy, sucrose density gradient ultracentrifugation, northern blotting, recombinant protein purification using prokaryotic expression system, and RNA sequence analysis, as evidenced by first author publications in peer-reviewed journals.
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ADVICE AND INSIGHTS FROM 亚洲天堂 FACULTY ON REACHING OUT TO SUPERVISORS
These videos contain some general advice from faculty across 亚洲天堂 on finding and reaching out to a potential thesis supervisor.
Supervision Enquiry
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Publications
- (2021)
EMBO Molecular Medicine, 13 (5) - (2021)
FEBS Letters, 595 (23), 2872--2896 - (2021)
Journal of proteomics, - (2020)
Nucleic Acids Research, - (2019)
EMBO reports, - (2019)
Nature structural & molecular biology, - (2019)
Scientific reports, - (2016)
- eEF2K inhibition blocks A尾42 neurotoxicity by promoting an NRF2 antioxidant response. (2016)
- (2015)
- (2015)
- (2014)
- (2013)
- (2013)
- (2012)
- (2010)
- Cloning of two chickpea cDNAs encoding calcium-dependent protein kinase isoforms (2007)
Current Science, - (2006)
- (2006)
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Membership Status
Partner appointment
View explanation of statuses
Location
Vancouver General Hospital
Program Affiliations
Academic Unit(s)
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