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Rationale: The relationship between age of symptom-onset and disease course is currently unknown in pediatric Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) patients. We aim to compare clinical characteristics and screen for genetic modifiers based on age at symptom-onset in pediatric CPVT patients diagnosed

Rationale: Clinical digital messaging (CDM) (text messaging) improves communication and engagement between adolescent patients and their health care providers (HCP). Dysautonomia of Adolescence (DAOA) is a condition which results in transient dysfunction of the autonomic nervous system (ANS). Many adolescents who are affected withdraw from school, sport, recreational activities; experience social isolation; and have significant mental health challenges. Quality of life (QoL) is severely affected, symptoms are difficult to predict and control. Ongoing support by HCP is needed to support management of symptoms. We sought to implement CDM to support DAOA patients and evaluate patient engagement, satisfaction, QoL and symptom burden.Methods: A single-centre, 12-month intervention study was performed. CDM was supported by WelTel Inc. Participants received an automated weekly check-in text message asking “How are you?”. Responses were triaged by HCP. QoL and symptom data were collected at three 6-month intervals: T0 baseline, T1 CDM enrollment and T2 post-CDM intervention. Non-parametric Friedman tests were used to determine differences over time. Participant engagement with the CDM platform was assessed through response rate and number of care conversations (>2 text messages between participant and HCP). Participant satisfaction was assessed using surveys administered at T1 and T2. Frequency counts (%) were performed for categorical variables and a univariate analysis performed on continuous variables. Tests were two-sided and a p